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Liverpool returned to football from the lockdown with a goalless draw against Merseyside rivals Everton on Sunday.
The draw left Liverpool five points away from the title, which they can claim with victories over Palace and Manchester City.
Meanwhile, Crystal Palace returned with a 2-0 win against AFC Bournemouth on Saturday.
The Eagles are currently enjoying one of their best ever seasons in the Premier League, sitting ninth with eight games to go.
James Milner and Joel Matip are doubt for Wednesday’s game after limping off in their game against Everton.
For Crystal Palace, Martin Kelly, Jeffrey Schlupp and James Tomkins all missed the Bournemouth victory and it remains to be seen who will recover in time for Wednesday.
Liverpool: Alisson; Alexander-Arnold, Gomez Van Dijk, Robertson; Henderson, Fabinho, Wijnaldum; Salah, Firmino, Mane.
Crystal Palace: Guaita; Ward, Dann, Cahill, Van Aanholt; Kouyate, Milivojevic, McArthur; Ayew, Benteke, Zaha.