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The Red Devils currently sit 10th in the Premier League table, two points and two places behind Graham Potter’s Seagulls.
Manchester United’s thin squad has been put to the test in recent times due to long term injuries to players like Paul Pogba, Eric Bailly and Timothy Fosu-Mensah.
There is some positive news in that Luke Shaw and Nemanja Matic have stepped up their training in recent days, but it is thought Sunday will be too soon for them. Axel Tuanzebe and Diogo Dalot will also most likely miss out.
Brighton, on the other hand, will be without South American duo Bernardo and Jose Izquierdo, who are both suffering from knee injuries. Adam Webster will also be a miss after he was stretchered off with an ankle problem in the victory over Norwich.
Summer signing Leandro Trossard could be in line for a start after impressive cameos against Everton and Norwich following his return from injury. Aaron Mooy is also back from suspension.
Brighton & Hove Albion
Ryan; Montoya, Duffy, Dunk, Burn; Stephens, Bissouma; Connolly, Mac Allister, Mooy; Maupay
De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Matic, Pogba; James, Fernandes, Rashford; Martial