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Southampton will be hoping to bounce back from a 2-1 home loss against Cardiff City to move out of the relegation zone.
Arsenal is currently fifth on the table with 50 points just a point below fourth-placed Manchester United.
Arsenal will not be with Danny Welbeck, Rob Holding, Hector Bellerin and Konstantinos Mavropanos who are all injured.
Southampton, on the other hand, will play without Mario Lemina and Danny Ings who are also injured.
In the last six meetings between the two sides, Arsenal have managed three wins, Southampton two and they have drawn once.
Arsenal (4-3-3): Leno; Mustafi, Koscielny, Monreal; Maitland-Niles, Torreira, Guendouzi, Kolasinac; Iwobi, Aubameyang; Lacazette
Southampton (3-5-2): McCarthy; Vestergaard, Stephens, Bednarek; Valery, Ward-Prowse, Hojbjerg, Romeu, Bertrand; Redmond, Long